교수진 소개
Feb. 1993: BS from Department of Chemistry, Pukyong National University.
Feb. 1995: MS from Department of Chemistry, Pukyong National University.
Feb. 2001: Ph D from Department of Pathology, Immunology and Microbiology, Graduate School of Medicine, University of Tokyo at Japan (Supervisor: Prof. T. Takenawa).
▶ Professional Experiences
2001 - 2006 : Postdoctoral Associate & Research Associate, Division of Biochemistry, Department of Cancer Biology, University of Tokyo, Japan
2006 - 2008 : Assistant Professor, Division of Biochemistry, Kobe University Graduate School of Medicine, Japan
2008.09 - 2012. 08 : Assistant Professor, Department of Chemistry, Pukyong National University
2012.09 - 2017.03 : Associate Professor, Department of Chemistry, Pukyong National University
2012.06 - 2014. 05 : Chairman, Department of Chemistry, Pukyong National University
2012.07 - 2014. 08 : Vice-Dean, College of National Science, Pukyong National University
2016.09 - 2018. 08 : Director, Research Institute for Basic Science, Pukyong National University
2017.03 - present : Professor, Department of Chemistry, Pukyong National University
▶ Professional Activities
- Professional Organization :
Journal of Korean Society for Biochemistry and Molecular Biology (KSBMB)
Journal of Korean Society for Molecular and Cellular Biology (KSMCB)
Journal of Korean Society for Biotechnology and Bioengineering (KSBB)
Journal of Korean Society of Life Science (KSLS)
- Referee for Grant Agency :
Korea Science and Engineering Foundation (KOSEF)
National Research Foundation (NRF)
▶ Professional Affiliations
- Member of Korean Society for Biochemistry and Molecular Biology (2009-present)
- Member of Korean Society for Molecular and Cellular Biology (2009-present)
- Member of Korean Society of Life Science (2009-present)
- Member of American Society for Cell Biology (2003-present)
- Member of Korean Chemical Society (2009-present)
▶ Grants
- Pukyong National University Research Fund for New Faculty (2008.9-2009.8) - Ministry of Education, Science, and Technology, NRF Grants for Basic Science Research Program (General Researcher Supporting Program-Female Scientist) (2009.5-2012.4)
- Ministry of Education, Science, and Technology, NRF Grants for Basic Science Research Program (General Researcher Supporting Program-New Faculty Scientist) (2010.5-2013.4)
- Korean Institute of Marine Science & Technology Promotion Fund (2012.1-2014.12)
- Ministry of Education, Science, and Technology, NRF Grants for Basic Science Research Program (General Researcher Supporting Program-General Scientist) (2012.9-2015.8)
- Ministry of Education, Science, and Technology, NRF Grants for Basic Science Research Program (General Researcher Supporting Program-General Scientist ) (2015.5-2018.4)
▶ Research Interests :
- Biochemistry/ Molecular Biological Chemistry/ Cell Biology/ Medicinal (Pharmaceutical) Chemistry
- Investigation on Molecular Mechanism of Human Diseases / Identification and Development of New Therapeutic Targets and Specific Inhibitors for Human Diseases
- 질병 유도/발생/진행에 관여하는 단백질 신호전달 네트워크를 분자 및 세포 수준에서 해명하고, 약물개발과 초기진단의 실용화에 연계하는 것을 목표로 함 (특정 표현형 변화 스크리닝, 단백질-단백질/생체분자 상호작용 규명, 표적 단백질(분자) 동정, 구조기반 새로운 활성소재 개발, 신규 생물화학 탐지자 개발)
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▶ Recent Publications
1 Kim YS, Li YX, Kim SK* and Park SJ* “Apoptotic effect of Demethoxyfumitremorgin C isolated from marine fungus Aspergillus fumigatus on PC3 human prostate cancer cells” Chemico-Biological Interaction, 2017 http://dx.doi.org/10.1016/j.cbi.2017.03.015
2 Ding YS, Kim WS, Kim SK* and Park SJ* “Apoptotic effect of physcion isolated from marine fungus, Microsporum sp. in PC3 human prostate cancer cells” Oncology Letters, 2017
3 Kim YS, Li YX, Kim SK* and Park SJ* “Aspergillus fumigatus-derived demethoxyfumitremorgin C induces growth inhibition of PC3 human prostate cancer cells by G1 arrest and apotosis” Journal of Microbiology and Biotechnology, 2017
4 Jang IS and Park SJ* “A Spirulina maxima-derived peptide inhibits HIV-1 infection” FAS, 2016 19:37 doi: 10.1186/s41240-016-0039-3
5 Kim YS and Park SJ* “Gliotoxin from the marine fungus Aspergillus fumigatus induces apoptosis in HT1080 fibrosarcoma cells by downregulating NF-B” FAS, 2016 19:35 doi: 10.1186/s41240-016-0036-6
6 Kim YA, Lee SH, Lee JH, Kang N, Oh JY, Heui S, Ahn G, Ko S, Fernando SP, Kim SY, Park SJ, Kim YT and Jeon YJ “A marine algal polyphenol, dieckol, attenuates blood glucose levels by Akt pathway in alloxaninduced hyperglycemia zebrafish model” RSC ADVANCES, 6: 78570？78575 (2016)
7 Ko JY, Kang N, Lee JH, Kim JS, Kim WS, Park SJ, Kim YT, Jeon YJ “Angiotensin I-converting enzyme inhibitory peptides from anenzymatic hydrolysate of flounder fish (Paralichthys olivaceus) muscleas a potent anti-hypertensive agent” PROCESS BIOCHEMISTRY PRBI-10611: 1？7 (2016)
8 Ko SC, Kim JI, Park SJ, Jeon YJ,* Jung WK** “Antihypertensive peptide purified from Styela clava flesh tissue stimulates glucose uptake through AMP activated protein kinase(AMPK) activation in skeletal muscle cells” European Research And Technolog, 242: 163, 2016 doi. 10.1007/s00217-015-2526-7
9 Jang IS and Park SJ* “Hydroxyproline-containing collagen peptide derived from Alaska pollack skin inhibits HIV-1 infection” Mol Medicine Report, 14(6): 5489-5494 (2016) doi: 10.3892/mmr.2016.5949.
10 Jung SH, Jeon YJ, and Park SJ* “Inhibitory effect of dieckol on hypoxia-induced epithelial-to-mesenchymal transition of HT29 human colorectal cancer cells” Mol Medicine Report. 14(6): 5148-5154 (2016) doi: 10.3892/mmr.2016.5872.
11 Kim WS, Jung WK, and Park SJ* “Antioxidant peptide derived from Spirulina maxima suppresses HIF1a-induced invasive migration of HT1080 fibrosarcoma cells” J. Chem. Volume 2015, Article ID 308602, 7 pages http://dx.doi.org/10.1155/2015/308602
12 Ahn CB, Jung WK, Park SJ, Kim YT, Kim YS, and Je JY？ “Gallic Acid-g-Chitosan Modulates Inflammatory Responses in LPS-Stimulated RAW264.7 Cells Via NF-κB, AP-1, and MAPK Pathways” Inflammation doi: 10.1007/s10753-015-0258-2 (2015)
13 Ko SC, Jung WK, Kang SM, Lee SH, Kang MC, Heo SJ, Kang KH, Kim YT, Park SJ, Jeong Y, Kim M, Byun HG,*, Jeon YJ,** “Angiotensin I-converting enzyme (ACE) inhibition and nitric oxide (NO)-mediated antihypertensive effect of octaphlorethol A isolated from Ishige sinicola: In vitro molecular mechanism and in vivo SHR model” J. Functional Foods 18: 289？299 (2015)
14 Kim YS, Hwang JW, Sung SH, Park SJ, Kim YT, Kim EK, Moon SH, Jeon BT, and Park PJ “Protective Effect of Carvacrol from Thymus quinquecostatus Celak against tert-Butyl Hydroperoxide-induced Oxidative Damage in Chang Cells” Food Sci. Biotechnol. 24(2): 735-741 (2015)
15 Manivasagan P, Venkatesan J, Kang KH, Sivakumar K, Park SJ, Kim SK？ “Production of α-amylase for the biosynthesis of gold nanoparticles using Streptomyces sp. MBRC-82” Int J Biol Macromol. 72:71-78 (2015)
16 Nguyen VT, Qian ZJ, Lee B, Heo SJ, Kim KN, Jeon YJ, Park WS, Choi IW, Jang CH, Ko SC, Park SJ, Kim YT, Kim GH, Lee DS, Yim MJ, Je JY and Jung WK* “Fucoxanthin derivatives from Sargassum silquiastrum inhibit matrix metalloproteinases by suppressing NF-kB and MAPKs in human fibrosarcoma cells” ALGAE 29(4): 355-366 (2014)
17 Jung SH, Jang IS, Jeon YJ, Kim YM, SJ Park* “Dieckol Suppresses CoCl2-induced Angiogenesis in Endothelial Cells” FAS 17(3), 305-311 (2014)
18 Park SJ, Tai S, Lee YJ, Jeon YJ, Kim YT？ “Overexpression and Refolding of BACE2” Journal of the Korean Fisheries Society 47(4), 370-375 (2014)
19 Vo TS, Ngo DH, Kang KH, Park SJ, Kim SK？, “The role of peptides derived from Spirulina maxima in down-regulation of FcεRI-mediated allergic responses” Mol Nutr Food Res. 58(11): 2226-2234 (2014)
20 Karadeniz F., Kang KH, Park JW; Park SJ, Kim SK？ “Anti-HIV-1 activity of phlorotannin derivative 8,4-dieckol from Korean brown alga Ecklonia cava” Bioscience Biotechnology And Biochemistry 78(7), 1151-1158 (2014)
21 Kim YT, Kim SK, Jeon YJ, SJ Park*, “Seahorse-derived peptide suppresses invasive migration of HT1080 fibrosarcoma cells by competing with intracellular a-enolase for plasminogen binding and inhibiting uPA-mediated activation of plasminogen” BMB reports. 47(1),1-7 (2014)
22 Eom TK, Ryu B, Lee JK, Byun HG, Park SJ, Kim SK？, “β-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides” Journal Of Enzyme Inhibition And Medicinal Chemistry 28(1):214-217 (2013)
23 Lee W, Ahn G, Lee BJ, Wijesinghe WA, Kim D, Yang H, Kim YM, Park SJ, Jee Y, Jeon YJ？. “Radio-protective effect of polysaccharides isolated from Lactobacillus brevis-fermented Ecklonia cava.” Int J Biol Macromol. 52:260-266 (2013)
24 SJ Park* and You Jin Jeon, “Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling” Molecules Cells. Feb 1(6): 141 ？ 149 (2012)
25 Yun Ji Yang, Se-Kwon Kim and SJ Park*, “An anti-inflammatory peptide isolated from seahorse inhibits the invasive potential of MG-63 osteosarcoma cells by inhibiting MMP expression downstream of Rac1-ROS signaling” Fisheries and Aquatic Sciences.15(1):29-36(2012)
26 SJ Park and Y. T. Kim？ “Expression of SARS-3CL Protease in a Cell-Free protein synthesis system” Journal of Life Science. 22(4): 552-228 (2012)
27 Kang MC, Ahn G, Yang X, Kim KN, Kang SM, Lee SH, Ko SC, Ko JY, Kim D, Kim YT, Jee Y, Park SJ, Jeon YJ？. “Hepatoprotective effects of dieckol-rich pholorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice” Food and Chemical Toxicology. 50: 1986-1991 (2012)
28 Ko SC, Kim DG, Han CH, Lee YJ, Lee JK, Byun HG, Lee SC, Park SJ, Lee DH, Jeon YJ？. “Nitric oxide-mediated vasorelaxation effects of anti-angiotensin I-converting enzyme (ACE) peptide from Styela clava flesh tissue and its anti-hypertensive effect in spontaneously hypertensive rats” Food Chemistry. 134: 1141-1145 (2012)
29 SJ Park*, Y. T. Kim, and Y. J. Jeon, “Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells” Molecules Cells.33(4):363-369 (2012)
30 Lee SH, Park MH, Park SJ, Kim J, Kim YT, Oh MC, Jeong Y, Kim M, Han JS, Jeon YJ？. “Bioactive compounds extracted from Ecklonia cava by using enzymatic hydrolysis protects high Glucose-induced damage in INS-1 pancreatic b-cells” Applied Biochemistry and Biotechnology. 5: 9695-9697 (2012)
31 Seok-Chun Ko, Nalae Kang, Eun-A. Kim, Min Cheol Kang, Seung-Hong Lee, Sung-Myung Kang,Joon-Baek Lee, Byong-Tae Jeon, Se-Kwon Kim, Sun-Joo Park, Pyo-Jam Park, Won-Kyo Jung, Daekyung Kim,？,1, You-Jin Jeon,？？,1 “A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from a marine Chlorella ellipsoidea and its antihypertensive effect in spontaneously hypertensive rats” Process Biochemistry 47: 2005-2011 (2012)
32 SJ Park*, and T. Takenawa, “Neural Wiskott-Aldrich syndrome protein is required for accurate congression and segregation of chromosomes” Molecules Cells. Jun; 31(6):515-521 (2011)
33 SJ Park*, “Huntingtin-interacting protein 1-related is required for accurate congression and segregation of chromosomes” BMB reports. December 31; 43(12):795-800 (2010)
34 Yamada H, Padilla-Parra S, Park SJ, Itoh T, Chaineau M, Monaldi I, Cremona O, Benfenati F, De Camilli P, Coppey-Moisan M, Tramier M, Galli T, Takei K. *, “Dynamic interaction of amphiphysin with N-WASP regulates actin assembly” J. Biol. Chem. December 4;284(49): 34244-34256 (2009)
35 Y. T. Kim, W. Nishii, M. Matsushima, H. Inoue, H. Ito, SJ Park* and K. Takahashi*, “Substrate specificities of porcine and bovine enteropeptidases toward the peptide Val-(Asp)4-Lys-Ile-Val-Gly and its analogs” Biosci. Biotechnol. Biochem. Mar. 72(3):905-8 (2008)
36 T. Kim, H.Yoshida, M. Kojima, R. Kurita, W. Nishii, T. Muramatsu, H. Ito, SJ Park* and K. Takahashi, “The effects of mutations in the carboxyl-terminal region on the catalytic activity of Escherichia coli signal peptidase I” J. Biochem. Feb. 143(2): 237-42 (2008)
37 SJ Park, S. Suetsugu, H. Sagara, and T. Takenawa*, “HSP90 cross-links branched actin filaments induced N-WASP and the Arp2/3 complex” Genes Cells. May. 12(5): 611-22 (2007)
38 SJ Park* and T. Takenawa*, “Regulation of actin polymerization by Rho family” PNE. May. 51 (6): 511-5 (2006)
39 SJ Park, S. Suetsugu, and T. Takenawa*, “Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation” EMBO J. Apr. 20;24(8): 1557-70 (2005)
40 SJ Park, T. Itoh and T. Takenawa*, “Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli” J. Biol. Chem. Feb. 16;276(7): 4781-7 (2004)
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